πŸ€• Blood clotting


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Upon disturbance of the cells lining a blood vessel, a cascade of events leads up to the coagulation of the blood and restoration of a protective barrier between the tissue and the environment, preventing further bleeding (hemostasis). Blood turns from a liquid to a gel. Many aspects that cause coagulation also contribute to defence against pathogens. For example, as the blood clots, it traps bacteria. Some clotting components are also toxic to some bacteria.

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Clotting begins with platelets forming a plug and initiating the release of clotting factors such as thromboplastin. This is a plasma protein which turns prothrombin to its active state, thrombin. Other clotting factors including calcium ions and vitamin K.

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Thrombin recruits soluble fibrinogen and converts it into insoluble fibrin which covers the wound and contributes to the platelet plug by strengthening it and aiding against pathogens and…