Upon disturbance of the cells lining a blood vessel, a cascade of events leads up to the coagulation of the blood and restoration of a protective barrier between the tissue and the environment, preventing further bleeding (hemostasis). Blood turns from a liquid to a gel. Many aspects that cause coagulation also contribute to defence against pathogens. For example, as the blood clots, it traps bacteria. Some clotting components are also toxic to some bacteria.
Clotting begins with platelets forming a plug and initiating the release of clotting factors such as thromboplastin. This is a plasma protein which turns prothrombin to its active state, thrombin. Other clotting factors including calcium ions and vitamin K.
Thrombin recruits soluble fibrinogen and converts it into insoluble fibrin which covers the wound and contributes to the platelet plug by strengthening it and aiding against pathogens and bleeding.
Good topic notes and cool videos. I'll definitely recommend it to my students.
Seema Sehgal AQA Examiner and biology teacher on LinkedIn
Just a huge thank you for spending your time helping others. I love your site and I'm seriously very grateful. No word of a lie
Neuron13 The Student Room
wow just checked out your website and think it’s pretty cool.
Eager bug The Student Room
You're such a G. Helped me so much, finally found someone who breaks biology down into something I can understand!!!
Alex Contact Form
Thank you for the help, your website and videos are awesome
pika mart YouTube