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βš–οΈ Principles of homeostasis and negative feedback

The internal environment of our bodies is constantly kept within strict limits. Take for example temperature. It must be a challenge keeping our fleshy selves at 37Β°C while the outside fluctuates wildly! Or how about blood glucose concentration? We’ve all heard of diabetes – if it goes too high our organs sustain damage, if it goes too low a coma may be induced or even death.

 

Welcome to homeostasis – the maintenance of physiological parameters within optimal range.

 

Core Body temperature and Blood pH

 

Why, though, is it so important to keep a strict temperature and pH? From a physiological viewpoint, think of enzyme activity. Its sensitivity to both temperature and pH means that the only conditions of optimal function will be strictly defined. Lots of enzymes denature past 40Β°C and are inactivated below…

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